Abnormal functions of alveolar macrophages from patients with pulmonary sarcoidosis.
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چکیده
منابع مشابه
Altered immunological reactivity in alveolar macrophages from patients with sarcoidosis.
Lung macrophages may play an important role in the pathogenesis of pulmonary sarcoidosis. In this study, the ability of pulmonary macrophages and blood monocytes from sarcoidosis patients, normal controls and disease controls to provide the accessory signal necessary for the concanavalin A-induced activation of normal blood T cells was examined. Blood monocytes from all groups supplied a signif...
متن کاملPulmonary alveolar proteinosis. Further evaluation of abnormal alveolar macrophages.
To investigate the function of alveolar macrophages (AM) and the mechanisms of impairment in pulmonary alveolar proteinosis, we established in culture AM from three patients and from eight normal nonsmokers and assessed phagocytosis and phagolysosome fusion by the acridine orange assay with live yeast as the phagocytic challenge. Alveolar macrophages from the patients with pulmonary alveolar pr...
متن کاملPulmonary alveolar proteinosis: abnormal in vitro function of alveolar macrophages.
Pulmonary alveolar proteinosis is characterized by the accumulation of granular proteinaceous material within the alveoli of the lung. It is well established that patients with pulmonary alveolar proteinosis have a high incidence of complicating pulmonary infections, which suggests that the function of the alveolar macrophages is abnormal. To investigate the function of these cells, they were o...
متن کاملCHROMOSOMAL PROTEINS IN PULMONARY ALVEOLAR MACROPHAGES
In this study the nature of chromosomal proteins, his tones and nonhistone in resident alveolar macrophages was investigated in comparison to peritoneal neutrophils and calf thymus proteins. Cells were obtained by lavaging the lung and after purity determination they were subjected to fractional extraction procedures. Proteins were then analysed on SDS polyacrylamide gels and densitometric...
متن کاملA STUDY OF 17 PATIENTS WITH PULMONARY SARCOIDOSIS IN MASHAD
Thirty patients with bilateral lymph node enlargement with or without parenchymal infiltrates on the chest x- ray suspected to have sarcoidosis were studied between June 1980 and December 1989 in our institution. Eleven of these patients who were free of parenchymal infiltrates did not have a biopsy performed and the diagnosis of sarcoidosis was made based on self-limited regression and cl...
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ژورنال
عنوان ژورنال: Journal of the Japan Society of the Reticuloendothelial System
سال: 1990
ISSN: 1883-6801,0386-9725
DOI: 10.3960/jslrt1961.30.39